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growth differentiation factor 11 (gdf11)  (PeproTech)


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    PeproTech growth differentiation factor 11 (gdf11)
    Growth Differentiation Factor 11 (Gdf11), supplied by PeproTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/growth+differentiation+factor+11+(gdf11)/gdf8+mstn/10__32604_slash_or__2025__064899-30-0-9
    Average 90 stars, based on 1 article reviews
    growth differentiation factor 11 (gdf11) - by Bioz Stars, 2026-08
    90/100 stars

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    Figure 5 Myostatin-specific inhibition by myostatin-b. HeLa cells cotransfected with Luc and Gal plasmids were treated with recombinant myostatin at concentrations of 0, 20, 40 and 60 ng/mL (A); recombinant growth differentiation factor 11 (GDF11) at concentrations of 0, 10, 20 and 30 ng/mL (B); recombinant transforming growth factor β1 (TGF-β1) at concentrations of 0, 0.5, 1 and 2 ng/mL (C); and activin A at concentrations of 0, 10, 20 and 30 ng/mL (D). In addition, the myostatin-b plasmid was cotransfected into each treated cell. The results of luciferase activity are shown. Myostatin-b inhibited myostatin signalling induced only by recombinant myostatin but not by recombinant GDF11, recombinant TGF-β1 or recombinant activin A (red bars). The data are expressed as the mean ± SEM of three independent experiments. **P < 0.01, ***P < 0.001. RLU, relative luminescence unit.

    Journal: Journal of cachexia, sarcopenia and muscle

    Article Title: A novel splice variant of the human MSTN gene encodes a myostatin-specific myostatin inhibitor.

    doi: 10.1002/jcsm.13314

    Figure Lengend Snippet: Figure 5 Myostatin-specific inhibition by myostatin-b. HeLa cells cotransfected with Luc and Gal plasmids were treated with recombinant myostatin at concentrations of 0, 20, 40 and 60 ng/mL (A); recombinant growth differentiation factor 11 (GDF11) at concentrations of 0, 10, 20 and 30 ng/mL (B); recombinant transforming growth factor β1 (TGF-β1) at concentrations of 0, 0.5, 1 and 2 ng/mL (C); and activin A at concentrations of 0, 10, 20 and 30 ng/mL (D). In addition, the myostatin-b plasmid was cotransfected into each treated cell. The results of luciferase activity are shown. Myostatin-b inhibited myostatin signalling induced only by recombinant myostatin but not by recombinant GDF11, recombinant TGF-β1 or recombinant activin A (red bars). The data are expressed as the mean ± SEM of three independent experiments. **P < 0.01, ***P < 0.001. RLU, relative luminescence unit.

    Article Snippet: After 24 h, the medium was replaced with serum-free RPMI 1640 or DMEM containing recombinant myostatin (788-G8, R&D Systems), recombinant growth differentiation factor 11 (GDF11) (1958-GD, R&D Systems), recombinant TGF-β1 (240-B/CF, R&D Systems) or recombinant activin A (338-AC/CF, R&D Systems).

    Techniques: Inhibition, Recombinant, Plasmid Preparation, Luciferase, Activity Assay

    GDF-11 expression levels are not varied in hGL cells and follicular fluid between normal and PCOS patients. A , and B , Follicular fluid samples were collected from 36 non-PCOS and 36 PCOS patients of similar age. The body mass index (BMI), antral follicle count (AFC), and basal levels of hormones in serum including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P4), and testosterone (T) were measured. C , GDF-11 protein levels in follicular fluid samples were measured by ELISA. D , GDF-11 mRNA levels in hGL cells obtained from 12 non-PCOS and 12 PCOS patients were measured by RT-qPCR. The clinical results are expressed as the mean ± SD

    Journal: Reproductive Biology and Endocrinology : RB&E

    Article Title: Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells

    doi: 10.1186/s12958-022-00912-7

    Figure Lengend Snippet: GDF-11 expression levels are not varied in hGL cells and follicular fluid between normal and PCOS patients. A , and B , Follicular fluid samples were collected from 36 non-PCOS and 36 PCOS patients of similar age. The body mass index (BMI), antral follicle count (AFC), and basal levels of hormones in serum including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P4), and testosterone (T) were measured. C , GDF-11 protein levels in follicular fluid samples were measured by ELISA. D , GDF-11 mRNA levels in hGL cells obtained from 12 non-PCOS and 12 PCOS patients were measured by RT-qPCR. The clinical results are expressed as the mean ± SD

    Article Snippet: GDF-11 protein levels in follicular fluid were measured using an ELISA Kit (#E-EL-H1908, Elabscience) as per the manufacturer’s instructions.

    Techniques: Expressing, Enzyme-linked Immunosorbent Assay, Quantitative RT-PCR